Clinical Chemistry Test Bank Chapter 18 (Amino Acids, peptides, and Proteins)

1- The isoelectric point of an amino acid or protein is defined as the:?




... Answer is C)
2- C-reactive protein (CRP) is considered an acute phase protein (APP) because its concentration in blood is increased quickly during inflammation. An example of a negative APP would be:?




... Answer is D)
3- The acid-base properties of amino acids are important in their function. Amino acids and proteins are both referred to as ampholytes. This means:?




... Answer is B)
4- The quaternary structure of a protein is the:?




... Answer is B)
5- The plasma protein that demonstrates a decreased serum concentration during an intravascular hemolytic disorder and is used to identify this occurrence is:?




... Answer is A)
6- Which one of the following proteins is the most abundant plasma protein in early embryonic life and is also measured to assess hepatocellular carcinoma in adults??




... Answer is A)
7- Hyperproteinemia is caused by:?




... Answer is D)
8- An increase in Bence-Jones protein in urine typically indicates the presence of paraproteins. What is Bence-Jones protein??




... Answer is B)
9- Which one of the following statements concerning albumin is not correct??




... Answer is D)
10- Known functions of proteins normally present in plasma include all of the following except?




... Answer is B)
11- The serum protein that is analyzed to determine the presence of emphysema is:?




... Answer is A)
12- Which of the following proteins are important in the regulation of circulating iron??




... Answer is C)
13- You operate a laboratory that receives many patient samples from the renal clinic next door. These patients have serious kidney problems, with causes that range from diabetes and IgA nephropathy to Fanconi syndrome. Would you expect to see elevated or decreased total urine protein from the patients that go to this clinic??


... Answer is A)
14- Albumin concentration in blood can be analyzed in an empty blood collection tube containing no anticoagulant. This means that you are analyzing:?




... Answer is A)
15- Serum proteins or protein complexes that precipitate at temperatures lower than normal core body temperature and that, if precipitated in tissues, result in vasculitis and ischemic injury to peripheral tissues are referred to as:?




... Answer is D)
16- At a physiological pH of 7.4, most amino acids:?




... Answer is B)
17- At a pH of 4.0, the:?




... Answer is B)
18- The element of protein structure that involves the folding of the polypeptide in three dimensions and the formation of disulfide bonds between cysteines is the _____ structure.?




... Answer is C)
19- Refractometry is a rapid, semiquantitative method of total protein determination. Which of the following will lead to a faulty interpretation of protein values obtained by refractometry??




... Answer is A)
20- Immunofixation electrophoresis:?




... Answer is B)
21- A malignant neoplasm that is composed of plasma cells that exhibit monoclonality and are diffusely present in the bone marrow is referred to as:?




... Answer is C)
22- The addition of sulfosalicylic acid for a qualitative turbidimetric protein determination of a urine specimen is done to:?




... Answer is D)
23- Analyses of free light chains, particularly immunoassays that measure the ratio of free - to free -light chains, are sensitive indicators of:?




... Answer is A)
24- The reference method for protein determination that converts nitrogen to ammonium ions by acid digestion is the:?




... Answer is C)
25- The proteins that are deposited in tissues as aggregates and that form B-sheet structures with eventual damage to the tissues are referred to as:?




... Answer is C)
26- A healthy 27-year-old pregnant woman in the second trimester sees her obstetrician for a routine visit. Blood and urine samples are obtained. Total serum protein and protein electrophoresis are performed on the blood sample and total urine protein is also analyzed. The results of the serum protein electrophoresis indicate a substantial increase in the a- globulin region of the electrophoretogram. Which of the a-globulins might this be and why??




... Answer is D)
27- A tumor of plasmacytoid cells that is diagnosed as Waldenström macroglobulinemia produces a paraprotein that is an:?




... Answer is D)
28- The most abundant complement protein component that is common to all three pathways of complement is:?




... Answer is B)
29- What is the globulin concentration of a specimen given the following information: total protein, 6.5 g/dL,and albumin,3.8 g/dL??




... Answer is A)
30- MATCHING Using each answer only once, match the metabolic disorder with the related plasma protein abnormality. -Elevated serum C-reactive protein?




... Answer is C)
31- MATCHING Using each answer only once, match the metabolic disorder with the related plasma protein abnormality. -Elevated retinol-binding protein?




... Answer is D)
32- MATCHING Using each answer only once, match the metabolic disorder with the related plasma protein abnormality. -Decreased serum ceruloplasmin?




... Answer is A)
33- MATCHING Using each answer only once, match the metabolic disorder with the related plasma protein abnormality. -Decreased haptoglobin?




... Answer is B)
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